The Role Of Myocarditis And Its Effect On The Body

Introduction: Inflammation is a key process by which the body responds to harmful stimuli, such as pathogens, injury, or chemical damage. This process leads to the recruitment of leukocytes that will function in the disposal of the harmful stimuli. However, there are times when this bodily response can lead to tissue damage and in some cases death. Myocarditis is a disease marked by inflammation of the heart muscle. Among the key regulators of inflammation are the IÃŽ ºB kinase (IKK) and its target NF-ÃŽ ºB, both of which play active roles in cardiac conditions. However, their precise inputs and functions are uncertain, alluring many researchers to further investigate. NF-ÃŽ ºB is a dimeric transcription factor composed of two identical monomers that’s consists of the subunits p50, p52, RelA, RelB, and c-REl. For the most part, NF-ÃŽ ºB is regulated within the cytoplasm by inhibitory ÃŽ ºB, Kappa Beta, proteins. However, upon physical, chemical, or biological stress, its activation pathway is stimulated, eventually resulting in the phosphorylation of IÃŽ ºB. From here, NF-ÃŽ ºB dimers are released, travel to the nucleus and alter the transcription of multiple target genes. Function of IKK/NF-ÃŽ ºB in the Heart: IÃŽ ºB kinase and NF-ÃŽ ºB (IKK/NF-ÃŽ ºB) activation are commonly implicated in myocarditis, heart failure, and inflammation-related cardiovascular diseases. However, much of their significance remains unclear. Recent studies involving mice, whose genes have been altered, have assisted inShow MoreRelatedUse the following Case Scenario896 Words   |  3 Pageslevels, serum creatinine levels, and signs and symptoms of congestion. Other serum tests such as BNP, liver function, D-dimer, and CBC are recommended. 1. IV furosemide (Lasix) – Administration of Lasix IV results in prompt diuretic effect (within 30 minutes). 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